N-Acetylcysteine Silver Nanoparticles as Antioxidant, Antimicrobial and Anti-cancerous against Sarcoma Male Rat Induced by 7,12 Dimethylbenz [a] Anthracene
Arwa H. AL-Saeed, Alyaa S. Jasam, Ali B. Aldeewan,
Muna H. AL-Saeed, Basil A. Abbas
The aim of this study is to investigate the biosynthesis of silver (Ag) nanoparticles using N-acetylcysteine (NAC) and effects of NAC-NPs on oxidative stress and sarcoma induced by 7,12 dimethylbenz[a]anthracene (DMBA) and antimicrobial. Silver nanoparticles are employed in many different fields, such as chemical and biological sensors, medicinal components, and catalysts. Studies on animals have demonstrated that chemicals are more carcinogenic to humans and animals. We examined sensitivity to a carcinogen in rats using a model of sarcomas-induction using a rarely performed subcutaneous injection of chemo-carcinogen. Male rats were injected with 150µg of 7,12-DMBA at 2 months,This caused 80% of the rats to develop sarcomas. In grossly observations Sarcomas form at the injection location. The result of NAC-AgNPs lead to significant (p≤0.05) weight gain and elevated body weight, CAT, SOD, GPx, MOP and TOS compared with DMBA group. The results showed significant decreas the MDA, ALP, AST, Calprotectin, IL-6, TNF-α, CRP, and TAS diameter and volume of tumors and significant (p<0.05) decreased the serum levels of serum p53 CA15.3 in therapeutic group. In the present investigation, silver nanoparticles were produced biologically by N-acetylcysteine (NAC) antioxidant, anticancer, anti-inflammatory, and their ability to combat harmful microbes with antibacterial properties We believe that these results could help clarify the mechanism underlying the formation of sarcomas in rats. NAC-AgNPs are one of the most popular applications for silver nanoparticles as antibacterial agents.
Keywords: Antioxidant, Anticancer, Antimicrobial, N-Acetylcysteine
