Association between Interluekine-10 and Bacterial Infection in Hemodialysis Patients
Duha Hussein Jiyad, Israa Saeed Abbas
Hemodialysis (HD) is a vital life-saving operation accounting for around 69% of all kidney replacement therapy and 89% of all dialysis, but dialysis has various issues, one of which is bloodstream infections (BSIs), which are the second leading cause of mortality in end-stage renal disease patients. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that helps to regulate the immunological response to infection. To study the correlated catheter-related blood stream infection with the clinical presentation of the patient group and the correlated IL-10 with a specific catheter-related blood stream infection. This is a case-control research conducted in the dialysis unit. The central venous catheter was used to collect 7 ml of blood from the patient and control groups, 5 ml of which was transferred to a blood culture container for culturing, and the remaining 2 ml was immediately deposited in a gel tube. Interleukin 10 was measured using conventional sandwich ELISA research kits. The results show that bacterial infection occurs in 48.6% of center venous catheter patients and 8.6% of arteriovenous fistula patients. IL-10 was high in patients with bacterial infection compared to patients without bacterial infection. Patients with center venous catheter types had more bacterial infections than arteriovenous fistulas. IL-10 levels were higher in patients with bacterial infections compared to patients without bacterial infections.
Keywords: Interleukin 10, Bacterial infection, Hemodialysis
