Novel Chemomarkers as Predictors of Left Ventricular Remodeling in Patients with Myocardial Infarction
Thulfiqar A. Mohammed, Entedhar R. Sarhat, Bashar M. Abid
The aim of this study to evaluate Serum Levels of brain natriuretic peptide, galectin-3, Ischemia modified albumin and IL-1-RA as Predictors of Left Ventricular Remodeling in patients with acute ST Elevation myocardial infarction (ST elevation of myocardial fraction). A total of 110 (62 patients and 48 control) enrolled in the present study. Forty-eight of apparently healthy sex and age matched control were included in this study. The data were collected from the control group (G1) composed of (48) individuals who were apparently healthy, the cases group as (G2) means: From the moment the patient arrives to internal resuscitation and up to 48 hours and at the baseline of the STEMI, and (G3) means: After 4-6 months follow up. serum levels of brain natriuretic peptide, galectin-3, Ischemia modified albumin, brain natriuretic peptide (BNP), and IL-1RA levels were quantified. The results of the study showed that the serum concentration of H Gal-3, IMA, and BNP were significantly higher in group G2 (patients group) in comparison to those of the G1(control group) P <0.01. However, the study also found that G3 group showed a significant reduction in serum H Gal-3 levels compared to G2 group at P <0.01. Regarding the IL-1RA mean concentration levels, the highest mean level (248.4±49) was seen among the G2 in matching to (222.9±43.5) for the control group at p<0.05. The current study concluded that there are significantly increasing of H Galectin 3, BNP and IMA levels in patients in matching to control groups. our study demonstrated that the concentration mean levels of IL-1RA was greater in patients in matching to control group. The current study showed highly significant (P<0.01) changes of Gal-3 levels in regards to LVR and Non LVR in G2 and G3. The levels of Gal-3 were higher of LVR patients than Non LVR. Our study showed highly significant results (P<0.01) between LVR and Non-LVR in regards to IL-1RA levels at G2.
Keywords: Left ventricular deficit, Professional development, Myocardial infarction, Ischemia modified albumin, Galectin 3, Brain natriuretic peptide, IL-1RA
