The Level of Heart-Type Fatty Acid Binding Protein (H-FABP) as Risk Marker for Cardiac Dysfunction among Some Beta-Thalassemia Major Patients in Baghdad City-Iraq
Ahmed J. Kadhim, Hedef .D. El-Yaseen, Ali M. Jawad
Beta thalassemia major (β-TM )is a prevalent genetic disorder due to a lack of globin chains. Heart-type fatty-acid binding protein (H-FABP) is a small protein in the cytoplasm released into the bloodstream when heart muscle cells are injured. H-FABP is regarded as a highly responsive indicator of continuous harm to the heart muscle and has the ability to predict cardiovascular problems in the overall population. This study aims to determine whether serum H-FABP levels in patients with thalassemia are significant and whether its concentration correlates with serum ferritin levels and cardiac enzymes. 60 subjects were included in this study to measure their serum H-FABP. 30 Beta-Thalassemia Major (β-TM )patients, none of them have symptoms of heart dysfunction, and 30 normal subjects were enrolled in this study. Serums H-FABP, Troponin-I, and BNP were determined using the ELISA technique in addition to serum Ferritin by a Clinical Automation system (Beckman Coulter). Serum H-FABP, Troponin-I, BNP, and Ferritin increased in β-TM patients compared to control healthy subjects (P < 0.001). A negative correlation was found between serum H-FABP and Troponin-I in the patients’ group. Elevated level of H-FABP and a negative correlation was found between serum H-FABP and Troponin-I in the β-TM Patients.
Keywords:Beta-Thalassemia Major, H-FABP, Troponin-I, BNP, Cardiac dysfunction
