Design and Enhancement Low-Level Laser Therapy System for Rheumatoid Arthritis
Ruaa A. Thajeel, Jamal A. Hasan, Dunia Tahseen Nema Al-Aridhi
Rheumatoid arthritis (RA) is inflammatory and autoimmune disease has a high prevalence in the population, while therapy is available, it often required injection of drugs causing discomfort to patients and side effect in most cases. The purpose of this study is to evaluate the clinical effect of low-level-laser-therapy (LLLT) with different wave length as an alternative treatment. This study is case control study. Forty-eight male rats were separated to six experimental groups: group I (negative control), group II (RA positive control), group III [RA treated with LLLT 650nm], group IV [RA treated with LLLT 910nm], group V [RA treated with LLLT 1064nm], and group VI [RA treated with methotrexate (RA+MTX)]. Paw measurement and Biochemical parameters for all groups [Rheumatoid-factor (RF), interleukin-6 (IL -6), interleukin-1β (IL-1β), tumor-necrosis-factor-alpha (TNF-α), malondialdehyde (MDA), and superoxide-dismutase (SOD)] were measured and analyzed statistically. There was a reduction in paw measurement due to LLLT effect after four weeks of therapy also there was a noticeable significant decrease in the levels of all biochemical parameters (IL-6, IL-1 β, TNF-α and MDA except the level of SOD, there was a significant increase as compared to the positive control group. LLLT effectively reduced inflammation signs in rat model of CFA but in different quantities, the effects of LLLT appear mostly in Nd:YAG laser with 1064 nm wavelength, intermediate effect in diode laser with 910 nm wavelength, and less effective in diode laser with 650nm wavelength.
Keywords: Rheumatoid arthritis, Low Level Laser Therapy, Anti inflammation, Nd, YAG laser
