Exploring the Correlation between Glycated Haemoglobin Levels and the Incidence of Renal Failure in Thi-Qar City: An In-Depth Investigation into Diabetes-Related Renal Complications
Zainab S. Hadawi, Mohammed Q. Sultan, Abbas Talib Abd Ali
The purpose of this prospective cohort research, which was carried out in Thi-Qar, Iraq, was to evaluate the intricate link that exists between the levels of glycated haemoglobi (HbA1c) and the beginning of renal failure in diabetic patients who were being treated with insulin. The research included the participation of 36 volunteers from a private laboratory. The participants were divided into two groups: 18 persons with well-managed diabetes and 18 individuals with poorly controlled diabetes. The study's objective was to better understand the biochemical and metabolic variations between the sexes, which are essential for improving diabetes care. During the period beginning on March 3, 2023, and ending on April 28, 2023, participants were subjected to rigorous examinations of their medical records and detailed blood sample analysis in order to keep a watchful eye out for any indications of renal failure. An investigation into the relationship between HbA1c levels and the beginning of renal failure was carried out using sophisticated statistical methods. This investigation took into consideration a number of potential confounding factors, including age, gender, length of time with diabetes, medication use, hypertension, dyslipidemia, and smoking behaviours. The outcomes of the research suggested that there were substantial differences in the levels of urea and HbA1c between the sexes, with females having higher values that are indicative of greater renal stress and less efficient glycemic management. The existence of gender-specific hazards and outcomes in diabetes care is highlighted by the biochemical differences that have been observed. It is important to note that the changes in creatinine and RBS levels did not reach the threshold of statistical significance, which suggests that these markers may not be able to capture the intricate adequately The findings of this cohort research highlight the need to develop individualised treatment programs and continuously monitor biochemical markers such as HbA1c to avoid renal failure and other problems that are associated with diabetes. Through the incorporation of comprehensive biochemical studies into clinical practice, treatment regimens may be better adapted to meet the specific physiological requirements of diabetes patients, both male and female. This results in an increase in the effectiveness of therapeutic interventions and an improvement in the overall outcomes for patients. This work not only contributes to the larger body of diabetes research but also paves the way for future research that will focus on improving diabetes management by using gender-specific insights.
Keywords: HbA1c, Renal failure, Diabetes, Thi-Qar city, Prospective cohort study
