Biochemical Test of Thyroid Gland and Allelic Frequency rs12917707 in Iraqi Patients with Thyroid Cancer
Noora Wael Rasheed
Thyroid cancer, one of the most common kinds of endocrine cancer, affects both sexes equally but is more prevalent in women. Several variables led to the development of this kind of cancer, such as genes and their polymorphism. This article evaluates the rs12917707 polymorphism associated with the UMOD gene that regulates several biochemical factors. The change in the blood concentration of these factors is associated with thyroid cancer. Blood samples were taken from 75 patients with thyroid cancer and 50 healthy controls. Then, genomic DNA was extracted, and the allelic and genotypic frequency of the rs12917707 polymorphism was determined using the TaqMan technique. In addition, the blood concentrations of biochemical components (T3, T4, TSH, vitamin D, RBC, WBC, PLT, and HGB) were evaluated using the ELISA technique. According to the data, the rs12917707 polymorphism is significantly associated with thyroid cancer susceptibility. The hormones T3, T4, TSH, and vitamin D are significantly associated with an elevated risk of thyroid cancer. In contrast, RBC, WBC, PLT, and HGB variables were not significantly associated with thyroid cancer. In general, genetic and biochemical components investigated in this work interact with the beginning of thyroid cancer.
Keywords: Cancer of the thyroid, Biochemical test, Polymorphism, rs12917707, Taqman
