Quantitative Determination of Trace Elements (Zn, Cu, And Mg) In Serum for Chronic Renal Failure Using Graphite Furnace Atomic Absorption GFAAS
Huda Ahmed Abd, Abdul Majeed Khorsheed Ahmed
Chronic kidney disease (CKD) is defined as a decrease in glomerular filtration rate, increased urinary albumin excretion, and, ultimately, complete loss of kidney function or kidney damage. This study was conducted in Kirkuk City from August 2023 to December 2023. The study involved collecting blood samples from 80 individuals with chronic kidney disease, aged 20-70 years, and 40 healthy individuals without any chronic diseases, aged 25-40 years The trace elements zinc, copper, and magnesium were quantitatively estimated in the blood serum of patients with kidney failure and the blood serum of healthy individuals using graphite non-flame atomic absorption spectroscopy (GFAAS). It was found that the concentration of zinc in the blood serum of patients with kidney failure was significantly lower (P < 0.0001) compared to the healthy group. The study also revealed that the copper concentration in patients with kidney failure was significantly higher (P < 0.0001) compared to the healthy group. Moreover, the study found that the concentration of magnesium in patients with kidney failure is significantly lower (P < 0.0001) compared to the healthy group. To investigate the effect of chronic kidney failure on the normal levels of trace elements zinc, copper, and magnesium, some of which were not previously measured in these patients at the dialysis center in Kirkuk.
Keywords: Chronic kidney disease, Zinc, Magnesium, Atomic absorption
