Dependable Spectrophotometric analytical determination of Amantadine in pharmaceutical formulation
Wisam Talib Hammadi, Sarhan Ali Salman
A simple, rapid, sensitive and accurate UV-spectrophotometric method has been developed for the estimation of Amantadine (AMT) in pharmaceutical formulation. The method was developed by using 0.1 N NaOH as a solvent and absorbance was measured at 780 nm. The proposed method is economical and sensitive for the estimation of AMT in bulk and tablet dosage form. The proposed methods spectrophotometric analysis was linear and in the range of 8- 40 µg/ ml at 780 nm with correlation coefficients (R2) of 0.9955. LOD and LOQ were found to be 3.576643 and 5.787704 respectively [SD: 0.474474135; SE: 0.212191284]. From the drug content analysis obtained, we could confirm the recovery to be 99.40% with a relative error less than or equal to 0.91 [SD: 0.0493; SE: 0.02848]. It is evident from these results that this method is applicable for the analysis of the drug in its bulk and tablet forms with comparable analytical performance.
Keywords: Spectrophotometric analytical Amantadine, Pharmaceutical formulation,
