Immune Modulatory effect of Curcumin NPs on Induced Osteoarthritis in Rats
Mahmood Nabeel Awad, Shatha Mousa Mlaghee
This experimental study, we investigated the immune-modulatory effects of curcumin nanoparticles (NPs) on induced osteoarthritis in rats. Thirty male albino rats were divided into six groups, with osteoarthritis induced in all groups except the negative control. Treatment groups received chitosan, curcumin-loaded on chitosan (150 mg/kg and 300 mg/kg), or ibuprofen. The preparation and characterization of curcumin NPs were described, and inflammatory markers (TNF-α, IL-6, IL-10) were assessed using ELISA. Results showed significant anti-inflammatory effects in the curcumin-treated groups, particularly with the higher dose of 300 mg/kg, supporting the potential of curcumin-loaded on chitosan NPs as a therapeutic approach for osteoarthritis management.
Keywords: Osteoarthritis, Curcumin nanoparticles, Chitosan, anti-inflammatory, Rats
