The impact of the COVID-19 infection during pregnancy on the placenta and its function-a cross sectional study
R. J. Al-Dahwi, D. Kostadinova-Slavova, M. A. Angelova,
G. D. Nikolova, Y. D. Karamalakova
This research aims at looking into how the coronavirus is likely to influence pregnancies in terms of placental function-important aspects. Global health is faced with unprecedented challenges by the coronavirus pandemic currently happening; pregnant women are particularly at risk because of the bodily changes and potential changes in their immune systems. Study conducted a cross-sectional investigation (March 2022 - March 2023) in Stara Zagora, Bulgaria, involving 15 healthy (31.1 ± 6.32 yrs) pregnant women and 20 pregnant women (33.1 ± 4.88 yrs) with SARS-Co-2. We aim to elucidate and understand COVID-19's effects on pregnant women and neonates. Gestational age at delivery of groups were 36 ± 0.8 and 37.6 ± 1.1. The newborn weight (g) was 3090.55 ± 400.1 gr for pregnant women with SARS-Co-2 and 3211±500.6 gr for controls (P<0.09). Usually, COVID-19 patients who needed intensive care are taken to NICU, where outcomes found three patients (15%) patients and two women with (13.3%) control. In this study, we assessed the outcomes of SARS-Co-2 pregnant woman and controls according to pathological placental patterns. We found that the placental weight in the SARS-Co-2 pregnant woman was 465 ± 50.5, larger than the controls (P<0.07). The preterm birth was found for six SARS-Co-2 patients (30%). The neonatal weight was 3390±190.1 g for the SARS-Co-2 pregnant woman versus 3720±110.1 g of controls (P= 0.001). Finally, the placental patterns and relationship between the VAS-QL that occur during late gestational age show evidence of vertical trans-placental SARSCoV-2 transmission and significant influence on perinatal results among newborns, especially with serious conditions, was discussed.
Keywords: SARS – CoV-2, Perinatal, Neonatal weight, Pregnancy, Placenta, VAS-QL
