The Biochemical and Hematological Changes in Laparoscopic Cholecystectomy
Mohammed Abdul Hameed Younis, Dr. Hussam Kareem, Dr. Wissem Hmida
Hematological indicators, including neutrophils, leukocytes, neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume, have been observed to change following laparoscopic surgery. Blood parameter and liver enzyme level changes following laparoscopic cholecystectomy are the focus of this investigation. Participants in this study were those who had symptomatic cholelithiasis and had a laparoscopic cholecystectomy. Those patients who had other medical conditions, such as hepatitis and diabetes, and those who had to change from laparoscopic cholecystectomy to open cholecystectomy were not included in the study. The pre-operative and post-operative Hematological parameters and liver function tests were documented. The noted features included body mass index (BMI), gender, age, surgery indication, and duration, the pneumoperitoneum pressure, and duration of hospital stay. Various hematological parameters mean pre and postoperative values were compared using a paired sample t-test. HCT (hematocrite), hemoglobin (Hb), platelets, and alkaline phosphatase (ALP) levels all decreased after surgery. After the procedure, there was an increase in mean corpuscular volume (MCV), mean platelet volume (MPV), leukocytes, and alanine transaminase (ALT). The mean values of Hb, MCV, Hct, leukocytes, MPV, and ALT showed a statistically significant difference (p<0.05). Significant alterations in hematological parameters and liver enzymes occurred during LC.
Keywords: Laparoscopic, Cholecystectomy, Liver Function Tests, Mean Platelet Volume, Cholelithiasis
